New building blocks of cell communication: How an invisible 'cap' could control electrical synapses

When two cells "talk" to each other, they often do so through tiny channels called electrical synapses. Unlike chemical ...
Worcester Polytechnic Institute (WPI)

Mending Broken Hearts

Biomedical engineering researcher Shijie Zhou brings a computational approach to the quest for better treatments for ...
News-Medical.Net

Blocking a ‘gerozyme’ reverses cartilage loss in mice

An injection that blocks the activity of a protein involved in aging reverses naturally occurring cartilage loss in the knee ...

Biology Breakthrough: Scientists Discover First New Plant Tissue in 160 Years – and It Supercharges Crop Yields

A research group led by Dr. Ryushiro Kasahara has discovered a new plant tissue essential for seed formation, which will be ...

Inhibiting a master regulator of aging regenerates joint cartilage in mice

An injection that blocks the activity of a protein involved in aging reverses naturally occurring cartilage loss in the knee ...
Scientific Research Publishing

Xu, C., Fan, C.D. and Wang, X. (2015) Regulation of Mdm2 Protein Stability and the p53 Response by NEDD4-1 E3 Ligase. Oncogene, 34, 281-289.

ABSTRACT: Objective: Nedd4-1 has been reported to be overexpressed in various human cancers. In this study, we investigated the role of Nedd4-1 in carcinogenesis and prognosis of cervical cancer.
Scientific Research Publishing

Persaud, A., Alberts, P., Hayes, M., Guettler, S., Clarke, I., Sicheri, F., et al. (2011) Nedd4-1 Binds and Ubiquitylates Activated FGFR1 to Control Its Endocytosis and ...

ABSTRACT: Objective: Nedd4-1 has been reported to be overexpressed in various human cancers. In this study, we investigated the role of Nedd4-1 in carcinogenesis and prognosis of cervical cancer.
Medicine Buffalo

Cardiac Clock Misalignment, Arrhythmias Focus of Study

Titled “Role of Cardiac Clock Misalignment in Promoting Arrhythmias in Swine and Donor Human Hearts,” the five-year, $3.4 million study is funded by a R01 grant from the National Heart, Lung and Blood ...