Computational framework streamlines therapeutic RNA nanocarrier design

A research team led by professor Olivia Merkel, Chair of Drug Delivery at LMU and co-spokesperson of the Cluster for Nucleic ...
Gut

Intraperitoneal translocation of gut microbiota induces NETosis and promotes endometriosis

Background Endometriosis is a debilitating gynaecological disorder with an elusive pathogenesis. While gut microbiota dysbiosis has been implicated, the causal role of gut-peritoneum microbial ...
eLife

TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

This study presents a valuable tool named TSvelo, a computational framework for RNA velocity inference that models transcriptional regulation and gene-specific splicing. The evidence supporting the ...

Lexogen Successfully Completes Large-Scale Human Primary Cell Next Gen Sequencing Project with Ochre Bio

Lexogen, a Vienna-based biotech company specialized in RNA transcriptomics technologies and services announces the completion ...
Pharmabiz

SPT Labtech, Pacific Biosciences to automate Kinnex full-length RNA-seq library preparation on SPT’s firefly liquid handling platform

SPT Labtech, Pacific Biosciences to automate Kinnex full-length RNA-seq library preparation on SPT’s firefly liquid handling platform: Cambridge, UK Monday, November 24, 2025, 1 ...

Study uncovers and predicts widespread molecular changes in ALS brain cells

Researchers at the University of Toronto's Temerty Faculty of Medicine have found widespread genetic and protein changes in ...
eLife

CNN-based learning of single-cell transcriptomes reveals a blood-detectable multi-cancer signature of brain metastasis

This important study describes a deep learning framework that analyzes single-cell RNA data to identify a tumor-agnostic gene signature associated with brain metastases. The identified signature ...
EurekAlert!

Ginkgo Datapoints launches the Virtual Cell Pharmacology Initiative to build a community-driven data standard for AI drug discovery

Ginkgo Datapoints has launched the Virtual Cell Pharmacology Initiative (VCPI), an open-source effort to create the first standardized framework for virtual cell modeling in drug discovery. By ...
Gut

FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis

Background Eosinophilic oesophagitis (EoE) is a chronic allergic disease characterised by oesophageal epithelial remodelling, barrier dysfunction and inflammation. The transcription factor forkhead ...
Morning Overview on MSN

Oldest RNA ever found reveals lives of woolly mammoths

In a groundbreaking scientific achievement, researchers have successfully extracted the world’s oldest RNA from a 40,000-year ...
EurekAlert!

An interpretable machine learning model for predicting 5‐year survival in breast cancer based on integration of proteomics and clinical data

Breast cancer is a highly heterogeneous malignancy among women worldwide. Traditional prognostic models relying solely on ...

World’s oldest RNA extracted from Ice Age woolly mammoth

Researchers at Stockholm University carefully ground up bits of muscle and other tissue from Yuka and nine other woolly mammoths, then used special chemical treatments to pull out any remaining RNA ...