The advent of next-generation sequencing has made possible genome analysis at previously unattainable depth. Roche, Illumina and Life Technologies, among others, have developed well-established ...

Abstract: Sequencing-by-synthesis technology takes us a step closer to the promises of personalized medicine by enabling affordable and fast DNA sequencing. Its accuracy, however, is fundamentally ...

Abstract: We consider the quasispecies spectrum reconstruction problem in amplicon reads. The main contribution of this paper is several methods to reconstruct HCV quasispecies from simulated ...

Rationale Genetic mechanisms fail to fully explain asthma pathogenesis and environmental factors are considered to play an important role. Environmental factors may lead to permanent changes in ...