Children with chronic inflammatory diseases suffer from severe growth failure associated with resistance toward the anabolic action of insulin-like growth factor I (IGF-I). We hypothesized that ...

Paltusotine vs placebo is associated with normalized insulin-like growth factor-1 (IGF-I), stable pituitary tumor size, significant symptom improvement, and sustained IGF-I reduction among adults with ...

Higher on-treatment serum insulin-like growth factor I levels may be associated with higher all-cause mortality risk among adults with acromegaly receiving the growth hormone blocker pegvisomant, ...

Among healthy adults, lower levels of circulating insulin-like growth factor I are associated with increased risk for fracture, with the risk more pronounced among men, according to findings from a ...

The mouse adipogenic cell line 1246 which possesses both insulin and insulin-like growth factor I (IGF-I) receptors was used to investigate the role of IGF-I and insulin on the proliferation of ...

Recent studies have demonstrated that insulin-like growth factor-1 (IGF-I) modulates bone mesenchymal stem cell chondrogenic differentiation independent of transforming growth factor beta (TGF-β) ...

November was a dreary month for those who had high hopes for insulin-like growth factor-1 as a treatment for neurodegenerative disorders. Though IGF-1 still has potential, therapies based on the ...

Opportunities exist in developing IGF-1R-targeted therapies for thyroid eye disease with proven market potential, and revisiting oncology applications using biomarker-driven patient stratification and ...