Homologous recombination is a DNA repair mechanism that counteracts double-stranded breaks in DNA. Researchers at Kindai University have recently revealed how the Sae2 protein coordinates with the ...

When an SSB appears, polymerase epsilon approaches the nick before retracing its steps thanks to its exonuclease, allowing fork reversal to take place. The nick is repaired as an SSB, and replication ...

How an enzyme involved in DNA repair becomes vital to the survival of certain cancers has been identified by scientists, paving the way for clinical trials evaluating the effects of blocking this ...

A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for improving cancer treatment outcomes. The result was published in Cell Death & ...

A novel technology combined with optical tweezer C-trap technology gives researchers new insight into DNA repair mechanisms. Researchers at the University of Pittsburgh (PA, USA) have developed a ...

Naked mole-rats are one of nature's most extraordinary creatures. These burrowing rodents can live for up to 37 years, around ten times longer than relatives of a similar size. But what is the secret ...

Researchers from Rice University and St. Jude Children’s Research Hospital in Memphis, Tennessee, took a close look at one of the ways cells repair broken strands of DNA and discovered details that ...

Better understanding of the mechanisms involved in DNA repair may pave the way for developing inhibitors to improve the effectiveness of radiation therapy. Nucleotide excision repair (NER) is a ...

Scientists at the University of Birmingham and the Francis Crick Institute have discovered a new way in which cancer cells repair double-stranded breaks in DNA. The findings were published in a paper ...

Scientists used magnetic tweezers to reveal how the RNA molecule ‘NIHCOLE’ repairs cell damage, hindering cancer treatments such as radiotherapy. If you want to defeat an enemy, one strategy you can ...

One of the biggest challenges in cancer treatment is chemoresistance: Tumors that initially respond well to chemotherapy become resistant over time. When that happens, treatment options are often ...